ChloroquineV1, Main, Exploration, bibRecord, 003816

Neutral proteinase inhibitors and antimetastatic effects in mice

Identifieur interne : 003816 ( Main/Exploration ); précédent : 003815; suivant : 003817

Neutral proteinase inhibitors and antimetastatic effects in mice

Auteurs : T. Giraldi [Italie] ; G. Sava [Italie] ; M. Kopitar [Slovénie] ; J. Brzin [Slovénie] ; V. Turk [Slovénie]

Source :

European Journal of Cancer (1965) [ 0014-2964 ] ; 1980.

RBID : ISTEX:E2B9DC07377FF0DDCE500637B7E6BB5300BA38B6

Descripteurs français

KwdFr :
- Acide aurintricarboxylique (usage thérapeutique), Animaux, Chloroquine (usage thérapeutique), Indométacine (usage thérapeutique), Inhibiteurs de protéases (usage thérapeutique), Métastase tumorale (), Phénylbutazone (usage thérapeutique), Souris, Souris de lignée C57BL, Tumeurs du poumon (secondaire), Tumeurs expérimentales ().
MESH :
- secondaire : Tumeurs du poumon.
- usage thérapeutique : Acide aurintricarboxylique, Chloroquine, Indométacine, Inhibiteurs de protéases, Phénylbutazone.
- Animaux, Métastase tumorale, Souris, Souris de lignée C57BL, Tumeurs expérimentales.

English descriptors

KwdEn :
- Animals, Aurintricarboxylic Acid (therapeutic use), Chloroquine (therapeutic use), Indomethacin (therapeutic use), Lung Neoplasms (secondary), Mice, Mice, Inbred C57BL, Neoplasm Metastasis (prevention & control), Neoplasms, Experimental (prevention & control), Phenylbutazone (therapeutic use), Protease Inhibitors (therapeutic use).
MESH :
- chemical , therapeutic use : Aurintricarboxylic Acid, Chloroquine, Indomethacin, Phenylbutazone, Protease Inhibitors.
- prevention & control : Neoplasm Metastasis, Neoplasms, Experimental.
- secondary : Lung Neoplasms.
Teeft :
- Acta biol, Animals, Antimetastatic, Antimetastatic effects, Aspirin, Aurintricarboxylic acid, Biochem, Carcinoma, Cathepsin, Chloroquine, Collagenase, Collagenolytic, Collagenolytic activity, Giraldi, Indomethacin, Inhibitor, Kopitar, Large metastases, Lewis lung carcinoma, Metastasis, Metastasis weight, Mice, Mice, Inbred C57BL, Neutral proteinase inhibitors, Neutral proteinases, Phenylbutazone, Primary tumor growth, Proteinase, Proteinase inhibitors, Same time, Significant reduction, Snpis, Tumor growth, Tumor implantation, Tumor weight.

Abstract

Abstract: The effects of a series of neutral proteinase inhibitors have been examined in mice bearing Lewis lung carcinoma. The substances tested are three non-steroidal anti-inflammatory agents (chloroquine, indomethacin and phenylbutazone), a broad spectrum non-specific enzyme inhibitor (aurintricarboxylic acid), and two intracellular inhibitors prepared from bovine spleen (SNPIs). All of these substances significantly reduced the formation of spontaneous pulmonary metastases. Primary lumor growth was unrelated with depression of metastasis formation, and a significant inhibition was caused by chloroquine and indomethacin only. These findings are consistent with previously reported inhibitory effects of non-steroidal anti-inflammatory agents on tumor development in animals, and indicate that, in addition to the suggested mechanisms, proteinase inhibition might be involved. They also support our previous observations on the antimetastatic effects caused in mice by neutral proteinase inhibitors.

Url:

https://api.istex.fr/ark:/67375/6H6-CD5DW622-J/fulltext.pdf

DOI: 10.1016/0014-2964(80)90224-8

Affiliations:

Italie, Slovénie

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Neutral proteinase inhibitors and antimetastatic effects in mice</title>
<author><name sortKey="Giraldi, T" sort="Giraldi, T" uniqKey="Giraldi T" first="T." last="Giraldi">T. Giraldi</name>
</author>
<author><name sortKey="Sava, G" sort="Sava, G" uniqKey="Sava G" first="G." last="Sava">G. Sava</name>
</author>
<author><name sortKey="Kopitar, M" sort="Kopitar, M" uniqKey="Kopitar M" first="M." last="Kopitar">M. Kopitar</name>
</author>
<author><name sortKey="Brzin, J" sort="Brzin, J" uniqKey="Brzin J" first="J." last="Brzin">J. Brzin</name>
</author>
<author><name sortKey="Turk, V" sort="Turk, V" uniqKey="Turk V" first="V." last="Turk">V. Turk</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:E2B9DC07377FF0DDCE500637B7E6BB5300BA38B6</idno>
<date when="1980" year="1980">1980</date>
<idno type="doi">10.1016/0014-2964(80)90224-8</idno>
<idno type="url">https://api.istex.fr/ark:/67375/6H6-CD5DW622-J/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000B59</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000B59</idno>
<idno type="wicri:Area/Istex/Curation">000B59</idno>
<idno type="wicri:Area/Istex/Checkpoint">002572</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002572</idno>
<idno type="wicri:doubleKey">0014-2964:1980:Giraldi T:neutral:proteinase:inhibitors</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:7398717</idno>
<idno type="wicri:Area/PubMed/Corpus">000612</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000612</idno>
<idno type="wicri:Area/PubMed/Curation">000612</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000612</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000582</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000582</idno>
<idno type="wicri:Area/Ncbi/Merge">001140</idno>
<idno type="wicri:Area/Ncbi/Curation">001140</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001140</idno>
<idno type="wicri:doubleKey">0014-2964:1980:Giraldi T:neutral:proteinase:inhibitors</idno>
<idno type="wicri:Area/Main/Merge">003895</idno>
<idno type="wicri:Area/Main/Curation">003816</idno>
<idno type="wicri:Area/Main/Exploration">003816</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">Neutral proteinase inhibitors and antimetastatic effects in mice</title>
<author><name sortKey="Giraldi, T" sort="Giraldi, T" uniqKey="Giraldi T" first="T." last="Giraldi">T. Giraldi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Istituto di Farmacologia, Università di Trieste, I-34100 Trieste</wicri:regionArea>
<wicri:noRegion>I-34100 Trieste</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sava, G" sort="Sava, G" uniqKey="Sava G" first="G." last="Sava">G. Sava</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Istituto di Farmacologia, Università di Trieste, I-34100 Trieste</wicri:regionArea>
<wicri:noRegion>I-34100 Trieste</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kopitar, M" sort="Kopitar, M" uniqKey="Kopitar M" first="M." last="Kopitar">M. Kopitar</name>
<affiliation wicri:level="1"><country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department of Biochemistry, J. Stefan Institute, University of Ljubljana</wicri:regionArea>
<wicri:noRegion>University of Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brzin, J" sort="Brzin, J" uniqKey="Brzin J" first="J." last="Brzin">J. Brzin</name>
<affiliation wicri:level="1"><country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department of Biochemistry, J. Stefan Institute, University of Ljubljana</wicri:regionArea>
<wicri:noRegion>University of Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Turk, V" sort="Turk, V" uniqKey="Turk V" first="V." last="Turk">V. Turk</name>
<affiliation wicri:level="1"><country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department of Biochemistry, J. Stefan Institute, University of Ljubljana</wicri:regionArea>
<wicri:noRegion>University of Ljubljana</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">European Journal of Cancer (1965)</title>
<title level="j" type="abbrev">EJCOLD</title>
<idno type="ISSN">0014-2964</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1980">1980</date>
<biblScope unit="volume">16</biblScope>
<biblScope unit="issue">4</biblScope>
<biblScope unit="page" from="449">449</biblScope>
<biblScope unit="page" to="454">454</biblScope>
</imprint>
<idno type="ISSN">0014-2964</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0014-2964</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Aurintricarboxylic Acid (therapeutic use)</term>
<term>Chloroquine (therapeutic use)</term>
<term>Indomethacin (therapeutic use)</term>
<term>Lung Neoplasms (secondary)</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Neoplasm Metastasis (prevention & control)</term>
<term>Neoplasms, Experimental (prevention & control)</term>
<term>Phenylbutazone (therapeutic use)</term>
<term>Protease Inhibitors (therapeutic use)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acide aurintricarboxylique (usage thérapeutique)</term>
<term>Animaux</term>
<term>Chloroquine (usage thérapeutique)</term>
<term>Indométacine (usage thérapeutique)</term>
<term>Inhibiteurs de protéases (usage thérapeutique)</term>
<term>Métastase tumorale ()</term>
<term>Phénylbutazone (usage thérapeutique)</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Tumeurs du poumon (secondaire)</term>
<term>Tumeurs expérimentales ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Aurintricarboxylic Acid</term>
<term>Chloroquine</term>
<term>Indomethacin</term>
<term>Phenylbutazone</term>
<term>Protease Inhibitors</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Neoplasm Metastasis</term>
<term>Neoplasms, Experimental</term>
</keywords>
<keywords scheme="MESH" qualifier="secondaire" xml:lang="fr"><term>Tumeurs du poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Lung Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Acide aurintricarboxylique</term>
<term>Chloroquine</term>
<term>Indométacine</term>
<term>Inhibiteurs de protéases</term>
<term>Phénylbutazone</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Acta biol</term>
<term>Animals</term>
<term>Antimetastatic</term>
<term>Antimetastatic effects</term>
<term>Aspirin</term>
<term>Aurintricarboxylic acid</term>
<term>Biochem</term>
<term>Carcinoma</term>
<term>Cathepsin</term>
<term>Chloroquine</term>
<term>Collagenase</term>
<term>Collagenolytic</term>
<term>Collagenolytic activity</term>
<term>Giraldi</term>
<term>Indomethacin</term>
<term>Inhibitor</term>
<term>Kopitar</term>
<term>Large metastases</term>
<term>Lewis lung carcinoma</term>
<term>Metastasis</term>
<term>Metastasis weight</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Neutral proteinase inhibitors</term>
<term>Neutral proteinases</term>
<term>Phenylbutazone</term>
<term>Primary tumor growth</term>
<term>Proteinase</term>
<term>Proteinase inhibitors</term>
<term>Same time</term>
<term>Significant reduction</term>
<term>Snpis</term>
<term>Tumor growth</term>
<term>Tumor implantation</term>
<term>Tumor weight</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Métastase tumorale</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Tumeurs expérimentales</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: The effects of a series of neutral proteinase inhibitors have been examined in mice bearing Lewis lung carcinoma. The substances tested are three non-steroidal anti-inflammatory agents (chloroquine, indomethacin and phenylbutazone), a broad spectrum non-specific enzyme inhibitor (aurintricarboxylic acid), and two intracellular inhibitors prepared from bovine spleen (SNPIs). All of these substances significantly reduced the formation of spontaneous pulmonary metastases. Primary lumor growth was unrelated with depression of metastasis formation, and a significant inhibition was caused by chloroquine and indomethacin only. These findings are consistent with previously reported inhibitory effects of non-steroidal anti-inflammatory agents on tumor development in animals, and indicate that, in addition to the suggested mechanisms, proteinase inhibition might be involved. They also support our previous observations on the antimetastatic effects caused in mice by neutral proteinase inhibitors.</div>
</front>
</TEI>
<affiliations><list><country><li>Italie</li>
<li>Slovénie</li>
</country>
</list>
<tree><country name="Italie"><noRegion><name sortKey="Giraldi, T" sort="Giraldi, T" uniqKey="Giraldi T" first="T." last="Giraldi">T. Giraldi</name>
</noRegion>
<name sortKey="Sava, G" sort="Sava, G" uniqKey="Sava G" first="G." last="Sava">G. Sava</name>
</country>
<country name="Slovénie"><noRegion><name sortKey="Kopitar, M" sort="Kopitar, M" uniqKey="Kopitar M" first="M." last="Kopitar">M. Kopitar</name>
</noRegion>
<name sortKey="Brzin, J" sort="Brzin, J" uniqKey="Brzin J" first="J." last="Brzin">J. Brzin</name>
<name sortKey="Turk, V" sort="Turk, V" uniqKey="Turk V" first="V." last="Turk">V. Turk</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003816 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003816 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:E2B9DC07377FF0DDCE500637B7E6BB5300BA38B6
   |texte=   Neutral proteinase inhibitors and antimetastatic effects in mice
}}

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

Serveur d'exploration Chloroquine

Neutral proteinase inhibitors and antimetastatic effects in mice

Neutral proteinase inhibitors and antimetastatic effects in mice

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.